NAP1L1 degradation by FBXW7 reduces the deubiquitination of HDGF-p62 signaling to stimulate autophagy and induce primary cisplatin chemosensitivity in nasopharyngeal carcinoma

NAP1L1 degradation by FBXW7 reduces the deubiquitination of HDGF-p62 signaling to stimulate autophagy and induce primary cisplatin chemosensitivity in nasopharyngeal carcinoma

Abstract Nucleosome assembly protein 1-like 1 (NAP1L1) has been implicated in promoting tumor cell proliferation. However, its role in regulating autophagy in tumors, including nasopharyngeal carcinoma (NPC), remains unclear. In this study, we observed that autophagy-inducing agents reduced NAP1L1 p...

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Main Authors: Bin Gong, Yahui Liu, Weiwei Yan, Chao Cheng, Huiling Yang, Jiyu Huang, Qing Liu, Yuyan Liu, Jiankang Guo, Xiaojie Deng, Beixian Zhou, Dayong Zheng, Xiong Liu, Zhen Liu, Weiyi Fang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
Subjects:
Autolysosomes
Autophagosomes
Chemosensitivity
E3 ubiquitin ligase
Ubiquitin degradation
Online Access:https://doi.org/10.1186/s12943-025-02349-z
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https://doi.org/10.1186/s12943-025-02349-z

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