Biomechanics of the tumor extracellular matrix and regulatory T cells: regulatory mechanisms and potential therapeutic targets

Biomechanics of the tumor extracellular matrix and regulatory T cells: regulatory mechanisms and potential therapeutic targets

Abstract Tumor-infiltrating regulatory T cells (TI-Tregs) are characterized by their abnormal accumulation and heightened immunosuppressive activity. However, the biomechanical mechanisms that govern Treg identity and function through extracellular matrix (ECM) properties remain poorly understood. I...

Full description

Saved in:
Bibliographic Details
Main Authors: Wen-Bo Huang, Heng-zhou Lai, Jing Long, Zhuo-ling Dai, Qiong Ma, Chong Xiao, Feng-Ming You
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cell Communication and Signaling
Subjects:
Regulatory T cells
Extracellular matrix
Biomechanics
Stiffness
Viscoelasticity
Online Access:https://doi.org/10.1186/s12964-025-02380-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12964-025-02380-z

Similar Items