Direct long-read visualization reveals hidden variation in GCH1 gene copy number and precise expansion steps

Direct long-read visualization reveals hidden variation in GCH1 gene copy number and precise expansion steps

Abstract Background Increases in the copy number of large genomic regions, termed amplifications, are an important adaptive strategy for many organisms. Numerous amplifications across the AT-rich Plasmodium falciparum genome contribute directly to drug resistance or impact the fitness of this protoz...

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Main Authors: Shiwei Liu, Julia Zulawinska, Emily R. Ebel, Aleksander Luniewski, Charles Danis, Mary Lewis Simpson, Jane Kim, Nnenna Ene, Thomas Werner Anthony Braukmann, Molly Congdon, Webster Santos, Ellen Yeh, Jennifer L. Guler
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Genomics
Subjects:
Oxford nanopore technology
Long-read sequencing
Single read visualization
Malaria
Plasmodium falciparum
Copy number variation
Online Access:https://doi.org/10.1186/s12864-025-11859-5
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https://doi.org/10.1186/s12864-025-11859-5

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