Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study
The mechanisms facilitating hypertension in diabetes still remain to be elucidated. Nonalcoholic fatty liver disease (NAFLD), which is a higher risk factor for insulin resistance, shares many predisposing factors with diabetes. However, little work has been performed on the pathogenesis of hypertens...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/5262560 |
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| author | Xiaoying Ding Ying Xu Yufan Wang Xiaohua Li Chunhua Lu Jing Su Yuhang Ma Yuting Chen Yanhua Yin Lijun Zhang Yong Wu Yaqiong Jin Lijun Zheng Songmei Xu Xiuli Zhu Jilin Ma Lihua Yu Junyi Jiang Naisi Zhao Qingwu Yan Andrew S. Greenberg Qianfang Huang Qian Ren Haiyan Sun Mingyu Gu Li Zhao Yunhong Huang Yijie Wu Chunxian Qian Yongde Peng |
| author_facet | Xiaoying Ding Ying Xu Yufan Wang Xiaohua Li Chunhua Lu Jing Su Yuhang Ma Yuting Chen Yanhua Yin Lijun Zhang Yong Wu Yaqiong Jin Lijun Zheng Songmei Xu Xiuli Zhu Jilin Ma Lihua Yu Junyi Jiang Naisi Zhao Qingwu Yan Andrew S. Greenberg Qianfang Huang Qian Ren Haiyan Sun Mingyu Gu Li Zhao Yunhong Huang Yijie Wu Chunxian Qian Yongde Peng |
| author_sort | Xiaoying Ding |
| collection | DOAJ |
| description | The mechanisms facilitating hypertension in diabetes still remain to be elucidated. Nonalcoholic fatty liver disease (NAFLD), which is a higher risk factor for insulin resistance, shares many predisposing factors with diabetes. However, little work has been performed on the pathogenesis of hypertension in type 2 diabetes (T2DM) with NAFLD. The aim of this study is to investigate the prevalence of hypertension in different glycemic statuses and to analyze relationships between NAFLD, metabolic risks, and hypertension within a large community-based population after informed written consent. A total of 9473 subjects aged over 45 years, including 1648 patients with T2DM, were enrolled in this cross-sectional study. Clinical and biochemical parameters of all participants were determined. The results suggested that the patients with prediabetes or T2DM were with higher risks to have hypertension. T2DM with NAFLD had significantly higher levels of blood pressure, triglyceride, uric acid, and HOMA-IR than those without NAFLD. Data analyses suggested that hypertriglyceridemia [OR = 1.773 (1.396, 2.251)], NAFLD [OR = 2.344 (1.736, 3.165)], hyperuricemia [OR = 1.474 (1.079, 2.012)], and insulin resistance [OR = 1.948 (1.540, 2.465)] were associated with the higher prevalence of hypertension independent of other metabolic risk factors in type 2 diabetes. Further studies are needed to focus on these associations. |
| format | Article |
| id | doaj-art-1331e1f7250d47c190a591fb3a4e98ec |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1331e1f7250d47c190a591fb3a4e98ec2025-02-03T06:05:57ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/52625605262560Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based StudyXiaoying Ding0Ying Xu1Yufan Wang2Xiaohua Li3Chunhua Lu4Jing Su5Yuhang Ma6Yuting Chen7Yanhua Yin8Lijun Zhang9Yong Wu10Yaqiong Jin11Lijun Zheng12Songmei Xu13Xiuli Zhu14Jilin Ma15Lihua Yu16Junyi Jiang17Naisi Zhao18Qingwu Yan19Andrew S. Greenberg20Qianfang Huang21Qian Ren22Haiyan Sun23Mingyu Gu24Li Zhao25Yunhong Huang26Yijie Wu27Chunxian Qian28Yongde Peng29Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Internal Medicine, Sijing Hospital, 389 Sitong Rd, Shanghai 201601, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Chronic Disease Prevention and Control, Sijing Community Health Service Center of Songjiang District, 108 North Jiangchuan Rd, Shanghai 201601, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Internal Medicine, Sijing Hospital, 389 Sitong Rd, Shanghai 201601, ChinaDepartment of Internal Medicine, Sijing Hospital, 389 Sitong Rd, Shanghai 201601, ChinaDepartment of Internal Medicine, Sijing Hospital, 389 Sitong Rd, Shanghai 201601, ChinaDepartment of Internal Medicine, Sijing Hospital, 389 Sitong Rd, Shanghai 201601, ChinaDepartment of Internal Medicine, Sijing Hospital, 389 Sitong Rd, Shanghai 201601, ChinaDepartment of Chronic Disease Prevention and Control, Sijing Community Health Service Center of Songjiang District, 108 North Jiangchuan Rd, Shanghai 201601, ChinaDepartment of Chronic Disease Prevention and Control, Sijing Community Health Service Center of Songjiang District, 108 North Jiangchuan Rd, Shanghai 201601, ChinaShanghai Pudong New Area Center for Disease Control and Prevention, 3039 Zhangyang Rd, Shanghai 200136, ChinaDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, USAObesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USAObesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USADepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Internal Medicine, Sijing Hospital, 389 Sitong Rd, Shanghai 201601, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaThe mechanisms facilitating hypertension in diabetes still remain to be elucidated. Nonalcoholic fatty liver disease (NAFLD), which is a higher risk factor for insulin resistance, shares many predisposing factors with diabetes. However, little work has been performed on the pathogenesis of hypertension in type 2 diabetes (T2DM) with NAFLD. The aim of this study is to investigate the prevalence of hypertension in different glycemic statuses and to analyze relationships between NAFLD, metabolic risks, and hypertension within a large community-based population after informed written consent. A total of 9473 subjects aged over 45 years, including 1648 patients with T2DM, were enrolled in this cross-sectional study. Clinical and biochemical parameters of all participants were determined. The results suggested that the patients with prediabetes or T2DM were with higher risks to have hypertension. T2DM with NAFLD had significantly higher levels of blood pressure, triglyceride, uric acid, and HOMA-IR than those without NAFLD. Data analyses suggested that hypertriglyceridemia [OR = 1.773 (1.396, 2.251)], NAFLD [OR = 2.344 (1.736, 3.165)], hyperuricemia [OR = 1.474 (1.079, 2.012)], and insulin resistance [OR = 1.948 (1.540, 2.465)] were associated with the higher prevalence of hypertension independent of other metabolic risk factors in type 2 diabetes. Further studies are needed to focus on these associations.http://dx.doi.org/10.1155/2017/5262560 |
| spellingShingle | Xiaoying Ding Ying Xu Yufan Wang Xiaohua Li Chunhua Lu Jing Su Yuhang Ma Yuting Chen Yanhua Yin Lijun Zhang Yong Wu Yaqiong Jin Lijun Zheng Songmei Xu Xiuli Zhu Jilin Ma Lihua Yu Junyi Jiang Naisi Zhao Qingwu Yan Andrew S. Greenberg Qianfang Huang Qian Ren Haiyan Sun Mingyu Gu Li Zhao Yunhong Huang Yijie Wu Chunxian Qian Yongde Peng Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study International Journal of Endocrinology |
| title | Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study |
| title_full | Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study |
| title_fullStr | Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study |
| title_full_unstemmed | Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study |
| title_short | Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study |
| title_sort | nonalcoholic fatty liver disease and associated metabolic risks of hypertension in type 2 diabetes a cross sectional community based study |
| url | http://dx.doi.org/10.1155/2017/5262560 |
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