Targeting mitochondrial ClpP: structural insights and therapeutic potential of ClpP agonists in cancer therapy

Mitochondrial “powerhouses” play a central function in cellular metabolism and energy generation. Their dysregulation is directly correlated with a myriad of diseases, among them cancer. The serine protease ClpP, accompanied by its cochaperone ClpX, is a principal homeostatic regulator in mitochondr...

Full description

Saved in:
Bibliographic Details
Main Authors: Mowei Kong, Yang Yu, Shuai Shao, Chunxiang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Oncology Reviews
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/or.2025.1567860/full
Tags: Add Tag
No Tags, Be the first to tag this record!