METTL3-mediated m6A modification regulates D-galactose-induced skin fibroblast senescence through miR-208a-5p

METTL3-mediated m6A modification regulates D-galactose-induced skin fibroblast senescence through miR-208a-5p

IntroductionAs the most abundant epitranscriptomic modification, N6-methyladenosine (m6A) critically influences aging and age-related pathologies. However, its regulatory interplay with microRNAs (miRNAs) in skin aging remains poorly defined.MethodsAging phenotypes were recapitulated using D-galacto...

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Main Authors: Gaoxiang Huang, Sainan Sun, Mingde Liao, Jing Wang, Qing Yan, Jing Li, Yi Meng, Qi Wang, Zhen Guo, Jiyong Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
aging
M6A
METTL3
miR-208a-5p
senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1577783/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1577783/full

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