Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up
BackgroundHematopoietic stem cell transplantation (HSCT) offers a potentially curative option for severe aplastic anemia (SAA). However, graft failure (GF) remains a life-threatening complication following HSCT. Haploidentical HSCT may serve as an effective salvage therapy for the treatment of GF.Ca...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607926/full |
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| author | Xuewei Li Xuewei Li Wenhui Zhang Wenhui Zhang Saisai Li Saisai Li Xiaolin Ma Xiaolin Ma Xue Shi Xue Shi Wei Wang Wei Wang Lingjie Sun Lingjie Sun Kuan Qiu Yanxia Zhao Yanxia Zhao Yanxia Zhao Chunting Zhao Chunting Zhao Xiaodan Liu Xiaodan Liu |
| author_facet | Xuewei Li Xuewei Li Wenhui Zhang Wenhui Zhang Saisai Li Saisai Li Xiaolin Ma Xiaolin Ma Xue Shi Xue Shi Wei Wang Wei Wang Lingjie Sun Lingjie Sun Kuan Qiu Yanxia Zhao Yanxia Zhao Yanxia Zhao Chunting Zhao Chunting Zhao Xiaodan Liu Xiaodan Liu |
| author_sort | Xuewei Li |
| collection | DOAJ |
| description | BackgroundHematopoietic stem cell transplantation (HSCT) offers a potentially curative option for severe aplastic anemia (SAA). However, graft failure (GF) remains a life-threatening complication following HSCT. Haploidentical HSCT may serve as an effective salvage therapy for the treatment of GF.Case presentationThis report describes a 3-year-old girl with acquired SAA who experienced GF twice following matched unrelated donor (MUD) transplantations. Successful engraftment was ultimately achieved through a third haploidentical donor HSCT. This work was conducted in accordance with the Declaration of Helsinki and the Declaration of Istanbul.ConclusionsBased on our experience with this case, we conclude that a third HSCT with a haploidentical donor represents a viable approach to extending survival. |
| format | Article |
| id | doaj-art-130050b3515648a3ba42d7ab2d1d3328 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-130050b3515648a3ba42d7ab2d1d33282025-08-20T03:28:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.16079261607926Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-upXuewei Li0Xuewei Li1Wenhui Zhang2Wenhui Zhang3Saisai Li4Saisai Li5Xiaolin Ma6Xiaolin Ma7Xue Shi8Xue Shi9Wei Wang10Wei Wang11Lingjie Sun12Lingjie Sun13Kuan Qiu14Yanxia Zhao15Yanxia Zhao16Yanxia Zhao17Chunting Zhao18Chunting Zhao19Xiaodan Liu20Xiaodan Liu21Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaChildren’s Medical Center, Department of Pediatric Hematology and Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaDepartment of Bone Marrow Transplantation, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, ChinaBackgroundHematopoietic stem cell transplantation (HSCT) offers a potentially curative option for severe aplastic anemia (SAA). However, graft failure (GF) remains a life-threatening complication following HSCT. Haploidentical HSCT may serve as an effective salvage therapy for the treatment of GF.Case presentationThis report describes a 3-year-old girl with acquired SAA who experienced GF twice following matched unrelated donor (MUD) transplantations. Successful engraftment was ultimately achieved through a third haploidentical donor HSCT. This work was conducted in accordance with the Declaration of Helsinki and the Declaration of Istanbul.ConclusionsBased on our experience with this case, we conclude that a third HSCT with a haploidentical donor represents a viable approach to extending survival.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607926/fullsevere aplastic anemiahematopoietic stem cell transplantationgraft failureimmune responseconditioning regimens |
| spellingShingle | Xuewei Li Xuewei Li Wenhui Zhang Wenhui Zhang Saisai Li Saisai Li Xiaolin Ma Xiaolin Ma Xue Shi Xue Shi Wei Wang Wei Wang Lingjie Sun Lingjie Sun Kuan Qiu Yanxia Zhao Yanxia Zhao Yanxia Zhao Chunting Zhao Chunting Zhao Xiaodan Liu Xiaodan Liu Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up Frontiers in Immunology severe aplastic anemia hematopoietic stem cell transplantation graft failure immune response conditioning regimens |
| title | Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up |
| title_full | Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up |
| title_fullStr | Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up |
| title_full_unstemmed | Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up |
| title_short | Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up |
| title_sort | successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia a case report with five year follow up |
| topic | severe aplastic anemia hematopoietic stem cell transplantation graft failure immune response conditioning regimens |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607926/full |
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