Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up

Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up

BackgroundHematopoietic stem cell transplantation (HSCT) offers a potentially curative option for severe aplastic anemia (SAA). However, graft failure (GF) remains a life-threatening complication following HSCT. Haploidentical HSCT may serve as an effective salvage therapy for the treatment of GF.Ca...

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Bibliographic Details
Main Authors: Xuewei Li, Wenhui Zhang, Saisai Li, Xiaolin Ma, Xue Shi, Wei Wang, Lingjie Sun, Kuan Qiu, Yanxia Zhao, Chunting Zhao, Xiaodan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
severe aplastic anemia
hematopoietic stem cell transplantation
graft failure
immune response
conditioning regimens
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607926/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607926/full

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