The ester derivative Palmitoylcarnitine abrogates cervical cancer cell survival by enhancing lipotoxicity and mitochondrial dysfunction

The ester derivative Palmitoylcarnitine abrogates cervical cancer cell survival by enhancing lipotoxicity and mitochondrial dysfunction

Abstract Background In cervical cancer (CC), Double C2 Like Domain Beta (DOC2B) functions as a metastatic suppressor. The present study aims to determine whether ectopic expression of DOC2B causes global metabolomic changes in extracellular vesicles (EVs) and corresponds with its tumor suppressive p...

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Bibliographic Details
Main Authors: Sangavi Eswaran, Roshan Mascarenhas, Shama Prasada Kabekkodu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Cervical cancer
DOC2B
Palmitoyl carnitine
Lipotoxicity
Reactive oxygen species
Mitochondria
Online Access:https://doi.org/10.1186/s12964-025-02218-8
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https://doi.org/10.1186/s12964-025-02218-8

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