Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers

Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers

Abstract Single‐cell MALDI mass spectrometry imaging (MSI) of lipids and metabolites >200 Da has recently come to the forefront of biomedical research and chemical biology. However, cell‐targeting and metabolome‐preserving methods for analysis of low mass, hydrophilic metabolites (<200 Da) in...

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Bibliographic Details
Main Authors: James L. Cairns, Johanna Huber, Andrea Lewen, Jessica Jung, Stefan J. Maurer, Tobias Bausbacher, Stefan Schmidt, Pavel A. Levkin, Daniel Sevin, Kerstin Göpfrich, Philipp Koch, Oliver Kann, Carsten Hopf
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
giant unilamellar vesicles (GUVs)
human induced pluripotent stem cells (hiPSC)
MALDI mass spectrometry imaging
microglia
neurodegeneration
single cell
Online Access:https://doi.org/10.1002/advs.202410506
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https://doi.org/10.1002/advs.202410506

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