Effect of tirzepatide-induced weight loss on adipose tissue in obesity: rationale and design of the randomized placebo-controlled Tirzepatide Brown and Beige Adipose Tissue Activation (TABFAT) trial

Effect of tirzepatide-induced weight loss on adipose tissue in obesity: rationale and design of the randomized placebo-controlled Tirzepatide Brown and Beige Adipose Tissue Activation (TABFAT) trial

Abstract Background Obesity is a complex disease marked by excessive, dysfunctional adipose tissue accumulation. Recent research underscores the pivotal role of brown adipose tissue (BAT) in metabolic health and its potential as a therapeutic target for obesity management. Emerging preclinical and c...

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Main Authors: Rok Herman, Mojca Jensterle, Simon Horvat, Luka Lezaic, Ziga Snoj, Igor Pusnik, Katja Goricar, Andrej Cör, Luka Pusnik, Vid Mlacnik, Lara Hanzelic, Andrej Janez
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Trials
Subjects:
Brown adipose tissue
Beige adipose tissue
Tirzepatide
Obesity
Online Access:https://doi.org/10.1186/s13063-025-09045-9
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https://doi.org/10.1186/s13063-025-09045-9

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