Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation

Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation

Abstract Background Ewing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to the formation of fusion proteins like EWS::FLI1. While several studies have shown that potassium channels drive the development of many tumours, limited data exi...

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Main Authors: Maryne Dupuy, Anaïs Postec, Mathilde Mullard, Aurélie Chantôme, Philippe Hulin, Régis Brion, Maxime Gueguinou, Laura Regnier, Marie Potier-Cartereau, Bénédicte Brounais-Le Royer, Marc Baud’huin, Steven Georges, François Lamoureux, Benjamin Ory, Françoise Rédini, Christophe Vandier, Franck Verrecchia
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
Ewing sarcoma
Potassium channels
KCNA2
Kv1.2 potassium channel
Proliferation
Hippo/YAP signalling pathway
Online Access:https://doi.org/10.1186/s12964-024-01981-4
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https://doi.org/10.1186/s12964-024-01981-4

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