Metformin carbon dots-based osteogenic and protein delivery system to promote bone regeneration in periodontitis

Metformin carbon dots-based osteogenic and protein delivery system to promote bone regeneration in periodontitis

The chronic inflammation in periodontitis suppresses the osteogenic potential of human periodontal ligament stem cells (hPDLSCs), posing a significant challenge to endogenous bone regeneration. To address this, we developed an osteogenic and protein-delivery composite hydrogel system based on metfor...

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Bibliographic Details
Main Authors: Jingjing Wei, Kai Wang, Yongkai Li, Jiao Huang, Ping Deng, Xianbo Xia, Cong Yang, Ling Xu, Junji Xu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
Metformin
Carbon dots
IGF-1
Osteogenic differentiation
Protein delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25002944
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http://www.sciencedirect.com/science/article/pii/S2452199X25002944

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