Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury

Anti-CD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury

Abstract Patients aged 65 years and older account for an increasing proportion of patients with traumatic brain injury (TBI). Older TBI patients experience increased morbidity and mortality compared to their younger counterparts. Our prior data demonstrated that by blocking α4 integrin, anti-CD49d a...

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Main Authors: Zhangying Chen, Kacie P. Ford, Mecca B. A. R. Islam, Hanxiao Wan, Hyebin Han, Abhirami Ramakrishnan, Ryan J. Brown, Veronica Villanueva, Yidan Wang, Booker T. Davis, Craig Weiss, Weiguo Cui, David Gate, Steven J. Schwulst
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-024-03257-7
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https://doi.org/10.1186/s12974-024-03257-7

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