Mechanistic basis of atypical TERT promoter mutations

Mechanistic basis of atypical TERT promoter mutations

Abstract Non-coding mutations in the TERT promoter (TERTp), typically at one of two bases −124 and −146 bp upstream of the start codon, are among the most prevalent driver mutations in human cancer. Several additional recurrent TERTp mutations have been reported but their functions and origins remai...

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Main Authors: Kerryn Elliott, Vinod Kumar Singh, Alan Bäckerholm, Linnea Ögren, Markus Lindberg, Katarzyna M. Soczek, Emily Hoberg, Tom Luijts, Jimmy Van den Eynden, Maria Falkenberg, Jennifer Doudna, Anders Ståhlberg, Erik Larsson
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54158-5
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https://doi.org/10.1038/s41467-024-54158-5

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