Identification of methionine metabolism related prognostic model and tumor suppressive functions of BHMT in hepatocellular carcinoma

Identification of methionine metabolism related prognostic model and tumor suppressive functions of BHMT in hepatocellular carcinoma

Abstract Given the resistance to conventional treatments and limitations of immune checkpoint blockade therapy in hepatocellular carcinoma (HCC), it is imperative to explore novel prognostic models and biomarkers. The dependence of cancer cell on exogenous methionine, known as Hoffman effect, is a h...

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Main Authors: Wenli Liu, Kaiheng Hu, Yaqing Fu, Tianmin Zhou, Qingmei Zhong, Wu Wang, Yang Gui, Ping Zhang, Di Yao, Xiaohong Yang, Weifeng Zhu, Zhuoqi Liu, Daya Luo, Yingqun Xiao
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Methionine metabolism
Lipid metabolism
Hepatocellular carcinoma
BHMT
Tumor microenvironment
Immunotherapy
Online Access:https://doi.org/10.1038/s41598-025-93650-w
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https://doi.org/10.1038/s41598-025-93650-w

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