Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier

Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier

Abstract The blood-brain barrier (BBB) restricts efficient penetration of systemically delivered therapeutic antibodies into the brain, limiting the development of this class of drugs to treat neurodegenerative diseases. Here we demonstrate that the neonatal Fc receptor (FcRn), which is highly expre...

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Main Authors: Julien Lafrance-Vanasse, Shraddha S. Sadekar, Yanli Yang, Daniela Bumbaca Yadav, William J. Meilandt, Monica K. Wetzel-Smith, Hao Cai, Susan R. Crowell, Van Nguyen, Vivian Lee, Ben Chih, Mandy Kwong, Pamela Chan, Sara Santagostino, Donna Lee, Shan Chung, Greg A. Lazar, James A. Ernst, Jasvinder K. Atwal
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59447-1
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https://doi.org/10.1038/s41467-025-59447-1

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