Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene

Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene

Abstract Numerous chemicals are associated with carcinogenesis through epigenetic alterations in cells. To detect global epigenetic changes induced by carcinogens, the housekeeping gene can serve as a reporter locus, offering a baseline for identifying shifts in epigenetic marks. To investigate this...

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Bibliographic Details
Main Authors: Haruto Yamada, Mizuki Odagiri, Keigo Yamakita, Aoi Chiba, Akiko Ukai, Manabu Yasui, Masamitsu Honma, Kei-ichi Sugiyama, Kiyoe Ura, Akira Sassa
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Toxicology
Epi-genotoxicity
Reporter assay
12-O-tetradecanoylphorbol-13-acetate
DNMT inhibitor
TK gene
Online Access:https://doi.org/10.1038/s41598-025-92121-6
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https://doi.org/10.1038/s41598-025-92121-6

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