MIP-3α-antigen fusion DNA vaccine enhances sex differences in tuberculosis model and alters dendritic cell activity early post vaccination

MIP-3α-antigen fusion DNA vaccine enhances sex differences in tuberculosis model and alters dendritic cell activity early post vaccination

Abstract Tuberculosis disease (TB) caused by Mycobacterium tuberculosis (Mtb) bacteria remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the Mtb infection. Bacterial persistence during exposure to...

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Main Authors: James T. Gordy, Rowan E. Bates, Elizabeth Glass, Jacob Meza, Yangchen Li, Courtney Schill, Alannah D. Taylor, Tianyin Wang, Fengyixin Chen, Khaleel Plunkett, Styliani Karanika, Petros C. Karakousis, Richard B. Markham
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Mycobacterium tuberculosis (Mtb)
Immunology sex differences
Antigen presenting cell (APC)
Dendritic cell (DC)
DNA vaccine
MIP-3α (CCL20)
Online Access:https://doi.org/10.1038/s41598-025-06532-6
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https://doi.org/10.1038/s41598-025-06532-6

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