Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome

Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome

Hemolytic uremic syndrome caused by an invasive Streptococcus pneumoniae infection (SP-HUS) is a rare and severe disease that primarily affects children under two years of age. The pathophysiology of SP-HUS remains poorly understood, and treatment is largely supportive. Complement factor H (FH) is a...

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Main Authors: Laura M. Baas, Kioa L. Wijnsma, Fokje Zijlstra, Nicole C. A. J. van de Kar, Lieke ter Steeg, Antonia H. M. Bouts, Marloes A. H. M. Michels, Jeroen D. Langereis, Dirk Lefeber, Hans J. C. T. Wessels, Lambertus P. van den Heuvel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
complement factor H
Streptococcus pneumoniae
hemolytic uremic syndrome
glycosylation
glycoproteomics
functional assays
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1645196/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1645196/full

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