Endothelial eNOS deficiency causes podocyte injury through NFAT2 and heparanase in diabetic mice

Endothelial eNOS deficiency causes podocyte injury through NFAT2 and heparanase in diabetic mice

Abstract The pivotal role of endothelial nitric oxide synthase (eNOS) in diabetic nephropathy (DN) has been demonstrated using global eNOS knockout (eNOSGKO) mice. However, the precise role of endothelially expressed eNOS and how its deficiency advances DN are still unclear. Here, we targeted endoth...

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Main Authors: Daisuke Katagiri, Shinya Nagasaka, Keiko Takahashi, Suwan Wang, Ambra Pozzi, Roy Zent, Akira Shimizu, Ming-Zhi Zhang, Joachim R. Göthert, Toin H. van Kuppevelt, Raymond C. Harris, Takamune Takahashi
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
eNOS
Diabetic nephropathy
NFAT2
Heparanase
Podocyte
Online Access:https://doi.org/10.1038/s41598-024-79501-0
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https://doi.org/10.1038/s41598-024-79501-0

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