Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells

Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells

Persistent activation of Signal Transducer and Activator of Transcription (STAT)3 occurs in a high percentage of tumors, including colorectal cancer (CRC), thereby contributing to malignant cell proliferation and survival. Although STAT3 is recognized as an attractive therapeutic target in CRC, conv...

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Main Authors: Federica Laudisi, Fabio Cherubini, Antonio Di Grazia, Vincenzo Dinallo, Davide Di Fusco, Eleonora Franzè, Angela Ortenzi, Illari Salvatori, Silvia Scaricamazza, Ivan Monteleone, Naoya Sakamoto, Giovanni Monteleone, Carmine Stolfi
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Molecular Oncology
Subjects:
anti‐apoptotic proteins
antisense oligonucleotide
cyclin D1
JAK‐STAT
SHP‐2
tumor‐infiltrating leukocytes
Online Access:https://doi.org/10.1002/1878-0261.12552
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https://doi.org/10.1002/1878-0261.12552

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