UBE2G2 inhibits vasculogenic mimicry and metastasis of uveal melanoma by promoting ubiquitination of LGALS3BP

UBE2G2 inhibits vasculogenic mimicry and metastasis of uveal melanoma by promoting ubiquitination of LGALS3BP

Uveal melanoma (UM) poses a significant lethality, with approximately 50% of those developing metastases surviving less than one year. In the progression of UM, vasculogenic mimicry (VM) induced by hypoxia plays a pivotal role, which also partially explains the resistance of UM to anti-angiogenic th...

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Bibliographic Details
Main Authors: Andi Zhao, Chenyu Zhou, Jinjing Li, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
UBE2G2
Vasculogenic mimicry
Invasion and metastasis
Uveal melanoma
Ubiquitination
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524003708
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