Evaluation of the Antinociceptive Effect of Sesamin: Role of 5HT<sub>1A</sub> Serotonergic Receptors

Evaluation of the Antinociceptive Effect of Sesamin: Role of 5HT<sub>1A</sub> Serotonergic Receptors

<b>Background/Objectives:</b> Sesame (<i>Sesamum indicum</i> L.) is used in folk medicine to treat painful disorders. Sesamin is the main lignan found in this plant; however, its antinociceptive potential has scarcely been studied. The aim was to investigate the antinocicepti...

Full description

Saved in:
Bibliographic Details
Main Authors: Roberto Camacho-Cruz, David Francisco Alcalá-Hernández, Juan Carlos Huerta-Cruz, Jesús Arrieta-Valencia, María Elena Sánchez-Mendoza, Francisco Javier Flores-Murrieta, Andrés Navarrete, Juan Gerardo Reyes-García, Héctor Isaac Rocha-González
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
diclofenac
gabapentin
inflammatory pain
neuropathic pain
serotonergic receptors
sesamin
Online Access:https://www.mdpi.com/1999-4923/17/3/330
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:<b>Background/Objectives:</b> Sesame (<i>Sesamum indicum</i> L.) is used in folk medicine to treat painful disorders. Sesamin is the main lignan found in this plant; however, its antinociceptive potential has scarcely been studied. The aim was to investigate the antinociceptive effect of sesamin on inflammatory and neuropathic pain models, as well as the possible mechanism of action through which sesamin mediates its own antinociceptive effect. <b>Methods:</b> Formalin and carrageenan animal models were used to assess inflammatory pain, whereas an L5/L6-spinal-nerve-ligated rat model was employed to evaluate neuropathic pain. <b>Results:</b> Oral sesamin significantly reduced carrageenan-induced hyperalgesia and inflammation, formalin-induced nociception, and L5/L6-spinal-nerve-ligation-induced allodynia. Sesamin was more effective than diclofenac in the inflammatory pain models, but it was less effective than pregabalin in the neuropathic pain model. The antinociceptive effect of sesamin, in the formalin test, was prevented by the intraperitoneal administration of methiothepin (5-HT<sub>1/5</sub> antagonist), but not by naltrexone (an opioid antagonist) or L-NAME (an NOS inhibitor). In addition, WAY-100635 (5-HT<sub>1A</sub> antagonist), but not SB-224289 (5-HT<sub>1B</sub> antagonist), BRL-15542 (5-HT<sub>1D</sub> antagonist), and SB-699551 (5-HT<sub>5A</sub> antagonist), impeded sesamin-induced antinociception. <b>Conclusions:</b> This study’s results support the use of sesamin to treat inflammatory pain disorders and suggest that 5-HT<sub>1A</sub> receptors influence the antinociceptive effect of this drug.
ISSN:1999-4923

Similar Items