Novel PiuC, PirA, and PiuA mutations leading to in vivo cefiderocol resistance progression in IMP-16- and KPC-2-producing Pseudomonas aeruginosa from a leukemic patient

Novel PiuC, PirA, and PiuA mutations leading to in vivo cefiderocol resistance progression in IMP-16- and KPC-2-producing Pseudomonas aeruginosa from a leukemic patient

ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen capable of causing severe infections in immunocompromised individuals, who often require prolonged antibiotic therapy. The emergence of carbapenemase-producing P. aeruginosa has further complicated the management of nosocomial infections,...

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Main Authors: Joaquim Viñes, Sabina Herrera, Andrea Vergara, Ignasi Roca, Jordi Vila, Tommaso Francesco Aiello, José Antonio Martínez, Ana del Río, Carlos Lopera, Carolina Garcia-Vidal, Climent Casals-Pascual, Àlex Soriano, Cristina Pitart
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
carbapenem-resistant
cefiderocol
PiuA
PiuC
PirA
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01928-24
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https://journals.asm.org/doi/10.1128/spectrum.01928-24

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