Anti-seizure effects of Datura stramonium: Impact on neurobehavior, antioxidant enzymes, and inflammatory markers in the hippocampus and amygdala of adult female Wistar rats using an isoniazid-induced epileptic model

Anti-seizure effects of Datura stramonium: Impact on neurobehavior, antioxidant enzymes, and inflammatory markers in the hippocampus and amygdala of adult female Wistar rats using an isoniazid-induced epileptic model

Background: Epilepsy, marked by recurrent seizures and neurochemical imbalances, remains a treatment challenge, particularly in resource-limited settings. Datura Stramonium (DS), a plant rich in tropane alkaloids like atropine, scopolamine, and hyoscyamine, has demonstrated potential pharmacologica...

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Bibliographic Details
Main Authors: Nto Johnson Nto, Somterimam Dogara Paul, Christian Mba, Godson Emeka Anyanwu, Uloaku Akubueze Nto-Ezimah, Emmanuel Obeagu, Chioma Ekenna-Ohanenye
Format: Article
Language:English
Published: Krishna Vishwa Vidyapeeth (Deemed to be University), Karad 2025-01-01
Series:Journal of Krishna Institute of Medical Sciences University
Subjects:
datura stramonium
neuroprotection
isoniazid-induced epilepsy
anti-seizure
oxidative stress
plant- based neurotherapy
neurotoxicity. carbamazepine
hippocampus
amygdala
Online Access:https://www.jkimsu.com/jkimsu-vol14no1/JKIMSU,%20Vol.%2014,%20No.%201,%20January-March%202025%20Page%2095-107.pdf
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https://www.jkimsu.com/jkimsu-vol14no1/JKIMSU,%20Vol.%2014,%20No.%201,%20January-March%202025%20Page%2095-107.pdf

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