Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

IntroductionGiven the complex etiological basis of Alzheimer’s disease (AD), it is reasonable to hypothesize that neuronal dysfunction and death result from the interplay of numerous factors, both genetic and environmental. Accumulating evidence implicates the immune system and inflammation as key c...

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Main Authors: Marta Matuszewska, Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Gabriela Olech-Kochańczyk, Ewelina Pałasz, Elżbieta Gawinek, Marcin Strawski, Grzegorz A. Czapski
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
prenatal exposure delayed effects
inflammation
beta amyloid
bromodomain containing proteins
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1619583/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2025.1619583/full

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