Investigation of Fructus sophorae extract’s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation

Investigation of Fructus sophorae extract’s therapeutic mechanism in atrophic vaginitis based on network pharmacology and experimental validation

ObjectiveThis study systematically elucidates the therapeutic mechanism of Fructus sophorae extract (FSE) against atrophic vaginitis (AV) by integrating network pharmacology with in vitro experimental validation.MethodsPotential drug targets of FS and AV-related disease targets were systematically r...

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Bibliographic Details
Main Authors: Jiarui Zheng, Weiming Wang, Wenting Song, Yehao Zhang, Mingjiang Yao, Guangrui Wang, Zishan Huang, Feng Li, Junguo Ren, Li Lin, Xiaodi Fan, Jianxun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
Fructus sophorae extract
atrophic vaginitis
network pharmacology
molecular docking
experimental verification
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1571976/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1571976/full

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