Ulinastatin inhibits macrophage M1 polarization to improve acute pancreatitis-associated intestinal barrier dysfunction by promoting Nrf2 signaling pathway activation

Ulinastatin inhibits macrophage M1 polarization to improve acute pancreatitis-associated intestinal barrier dysfunction by promoting Nrf2 signaling pathway activation

Abstract Background Intestinal barrier dysfunction plays a significant role in the development of pancreatic necrosis and multiple organ failure in AP. This study aimed to investigate the therapeutic effects and potential mechanisms of ulinastatin (UTI) on L-arginine-induced acute pancreatitis (AP)-...

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Bibliographic Details
Main Authors: Qi Wang, Jiahui Fang, Siqi Zhang, Ming Gao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Ulinastatin
Acute pancreatitis
Intestinal barrier dysfunction
Macrophage polarization
Nrf2 signaling pathway
Online Access:https://doi.org/10.1186/s40001-025-02952-2
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https://doi.org/10.1186/s40001-025-02952-2

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