Enhancing Stability and Investigating Target Attainment of Benzylpenicillin in Outpatient Parenteral Antimicrobial Therapy: Insights from In Vitro and In Vivo Evaluations

Enhancing Stability and Investigating Target Attainment of Benzylpenicillin in Outpatient Parenteral Antimicrobial Therapy: Insights from In Vitro and In Vivo Evaluations

<b>Background/Objective</b>: Narrow-spectrum beta-lactam antibiotics such as benzylpenicillin and flucloxacillin are increasingly used in outpatient parenteral antimicrobial therapy (OPAT) programs to mitigate the adverse effects associated with broad-spectrum antibiotics. These beta-lac...

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Bibliographic Details
Main Authors: Katharina M. Rentsch, Nina Khanna, Delia Halbeisen, Michael Osthoff
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Antibiotics
Subjects:
benzylpenicillin
therapeutic drug monitoring
stability
degradation
OPAT
Online Access:https://www.mdpi.com/2079-6382/13/10/970
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