Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country
Shigellosis is an acute infectious disease characterized as severe bloody diarrhea (dysentery) and is accountable for a significant burden of morbidity and mortality especially in children under the age of 5 years. Antimicrobial therapy is required in the cases of severe dysentery associated with Sh...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2017/1862320 |
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| author | Narayan Prasad Parajuli Govardhan Joshi Bashu Dev Pardhe Jyotsna Shakya Anjeela Bhetwal Shreena Shakya Roshan Pandit Sumesh Shreekhanda Shrestha Puspa Raj Khanal |
| author_facet | Narayan Prasad Parajuli Govardhan Joshi Bashu Dev Pardhe Jyotsna Shakya Anjeela Bhetwal Shreena Shakya Roshan Pandit Sumesh Shreekhanda Shrestha Puspa Raj Khanal |
| author_sort | Narayan Prasad Parajuli |
| collection | DOAJ |
| description | Shigellosis is an acute infectious disease characterized as severe bloody diarrhea (dysentery) and is accountable for a significant burden of morbidity and mortality especially in children under the age of 5 years. Antimicrobial therapy is required in the cases of severe dysentery associated with Shigella. However, emergence of multidrug resistant (MDR) strains of Shigella spp. over the last two decades has restricted the use of common therapeutic antimicrobials. In MDR strains, the third-generation cephalosporins have been used for the treatment, but, unfortunately, emerging reports of enzyme mediated β-lactam resistance among Shigella isolates from various parts of the world have greatly compromised the therapy of pediatric dysentery. In Nepal, drug resistant strains of Shigella spp. have been reported, but MDR and extended spectrum β-lactamase (ESBL) producing strains were previously unknown. Here, we report two Shigella flexneri isolates harboring ESBL genotype-CTX-M associated with acute dysentery in two siblings which were presented and treated in a tertiary care teaching hospital of Kathmandu, Nepal. |
| format | Article |
| id | doaj-art-11f651649e9a4f43bc16bdd78156dcca |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-11f651649e9a4f43bc16bdd78156dcca2025-02-03T06:07:31ZengWileyCase Reports in Infectious Diseases2090-66252090-66332017-01-01201710.1155/2017/18623201862320Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the CountryNarayan Prasad Parajuli0Govardhan Joshi1Bashu Dev Pardhe2Jyotsna Shakya3Anjeela Bhetwal4Shreena Shakya5Roshan Pandit6Sumesh Shreekhanda Shrestha7Puspa Raj Khanal8Department of Clinical Laboratory Services, Manmohan Memorial Medical College and Teaching Hospital, Kathmandu, NepalDepartment of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, NepalDepartment of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, NepalDepartment of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, NepalDepartment of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, NepalDepartment of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, NepalDepartment of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, NepalDepartment of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, NepalDepartment of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, NepalShigellosis is an acute infectious disease characterized as severe bloody diarrhea (dysentery) and is accountable for a significant burden of morbidity and mortality especially in children under the age of 5 years. Antimicrobial therapy is required in the cases of severe dysentery associated with Shigella. However, emergence of multidrug resistant (MDR) strains of Shigella spp. over the last two decades has restricted the use of common therapeutic antimicrobials. In MDR strains, the third-generation cephalosporins have been used for the treatment, but, unfortunately, emerging reports of enzyme mediated β-lactam resistance among Shigella isolates from various parts of the world have greatly compromised the therapy of pediatric dysentery. In Nepal, drug resistant strains of Shigella spp. have been reported, but MDR and extended spectrum β-lactamase (ESBL) producing strains were previously unknown. Here, we report two Shigella flexneri isolates harboring ESBL genotype-CTX-M associated with acute dysentery in two siblings which were presented and treated in a tertiary care teaching hospital of Kathmandu, Nepal.http://dx.doi.org/10.1155/2017/1862320 |
| spellingShingle | Narayan Prasad Parajuli Govardhan Joshi Bashu Dev Pardhe Jyotsna Shakya Anjeela Bhetwal Shreena Shakya Roshan Pandit Sumesh Shreekhanda Shrestha Puspa Raj Khanal Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country Case Reports in Infectious Diseases |
| title | Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country |
| title_full | Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country |
| title_fullStr | Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country |
| title_full_unstemmed | Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country |
| title_short | Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country |
| title_sort | shigellosis caused by ctx m type esbl producing shigella flexneri in two siblings of rural nepal first case report from the country |
| url | http://dx.doi.org/10.1155/2017/1862320 |
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