Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.

The human dopamine transporter (hDAT) is located on presynaptic neurons, where it plays an essential role in limiting dopaminergic signaling by temporarily curtailing high neurotransmitter concentration through rapid re-uptake. Transport by hDAT is energized by transmembrane ionic gradients. Dysfunc...

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Bibliographic Details
Main Authors: Kumaresan Jayaraman, Alex N Morley, Daniel Szöllősi, Tsjerk A Wassenaar, Harald H Sitte, Thomas Stockner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Computational Biology
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1006229/2/pcbi.1006229.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210223%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210223T051254Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=30f46cf87885adfc8ce193b9cd05d6ee15efabdb101db1900ce89711718a6bfb01eaa4ec2e7bdc894bba5aed83582395b18939820cfd069f74eb4bdf936d189d518aa591ef10bb84bcc4c13626e63e3e3af24d56e2eb764a89d14cb1d2531a03b9ac859f96cb0a29535c50f842b5df898e5a7dbc65e3c57b7c9273e090a9f2f2bd28f409665b792465d2c1c92db1ac9fe054243b196492f9689dd579e3f7185be26dd39e189cb075098f5046a90622dd5b1aa017bbddae481e8967067a8ecfbbbf43942d05ff372f2667a29a6c4a6cf5d477d739de452ffee6c2d3fb9f232cde2f9cbda3775adf38bcc2f516bc6f0a36d9cb7089aa3cce8bdbd8d921d95223ff
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