A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.

A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.

Numerous genetic and epigenetic alterations render cancer cells selectively dependent on specific genes and regulatory pathways, and represent potential vulnerabilities that can be therapeutically exploited. Here we describe an RNA interference (RNAi)-based synthetic interaction screen to identify g...

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Bibliographic Details
Main Authors: Li Xie, Claude Gazin, Sung Mi Park, Lihua J Zhu, Marie-anne Debily, Ellen L W Kittler, Maria L Zapp, David Lapointe, Stephane Gobeil, Ching-Man Virbasius, Michael R Green
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003151&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003151&type=printable

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