Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

An important component in the development of efficacious vaccines is the optimization of vaccination schedules to elicit protective immunity, especially in a vulnerable group like infants. Mucosal IgA plays an important role in the initial defense at mucosal surfaces, protecting against the coloniza...

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Main Authors: Poorya Foroutan Pajoohian, Audur Anna Aradottir Pind, Jenny Lorena Molina Estupiñan, Dennis Christensen, Gabriel Kristian Pedersen, Thorunn A. Olafsdottir, Ingileif Jonsdottir, Stefania P. Bjarnarson
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
neonatal vaccination
heterologous immunization routes
antibody-secreting cells
antibody levels
mucosal immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563345/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563345/full

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