Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death

Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death

Abstract Background Long QT Syndrome Type-2 (LQT2) is due to loss-of-function KCNH2 variants. KCNH2 encodes Kv11.1 that forms a delayed-rectifier potassium channel in the brain and heart. LQT2 is associated with arrhythmias, seizures, sudden cardiac death, and sudden unexpected death in epilepsy (SU...

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Bibliographic Details
Main Authors: Veronica Singh, Kyle T. Wagner, Laura G. Williams, Justin M. Ryan, Katherine R. Keller, Jonathan D. Mohnkern, Robert S. Gardner, Louis T. Dang, Julie M. Ziobro, Richard J. H. Wojcikiewicz, Nathan R. Tucker, David S. Auerbach
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Arrhythmia
Seizure
Epilepsy
Long QT syndrome
Rabbit
KCNH2
Online Access:https://doi.org/10.1186/s12967-025-06382-w
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https://doi.org/10.1186/s12967-025-06382-w

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