PGD2/PTGDR2 signaling pathway affects the self-renewal capacity of gastric cancer stem cells by regulating ATG4B ubiquitination

PGD2/PTGDR2 signaling pathway affects the self-renewal capacity of gastric cancer stem cells by regulating ATG4B ubiquitination

BackgroundProstaglandin D2 (PGD2) inhibits the development of different malignant tumors; however, the underlying mechanism of inhibiting tumor development is not yet clear. This study aimed to elucidate how PGD2 inhibits the stemness of gastric cancer stem cells (GCSCs) via autophagy and its underl...

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Bibliographic Details
Main Authors: Qiang Zhang, HengJin Tian, Kunpeng Ge, FeiFan Wang, PeiYao Gao, AMin Chen, Lulu Wang, YanMing Zhao, Chaoqun Lian, FengChao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Oncology
Subjects:
gastric cancer
cancer stem cells
PTGDR2
autophagy
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1496050/full
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https://www.frontiersin.org/articles/10.3389/fonc.2024.1496050/full

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