Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applications

Abstract The niche microenvironment plays a crucial role in regulating the fate of normal skin stem cells (SSCs) and cancer stem cells (CSCs). Therapeutically targeting the CSC niche holds promise as an effective strategy; however, the dual effects of shared SSC niche signaling in CSCs have contribu...

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Bibliographic Details
Main Authors: Trang Thao Quoc Pham, Yung-Che Kuo, Wei-Ling Chang, Hao-Jui Weng, Yen-Hua Huang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
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Online Access:https://doi.org/10.1186/s12943-025-02289-8
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