Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α
Objectives. In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs. The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte tel...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/7610436 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550953033662464 |
|---|---|
| author | Jie Yu Haibin Liu Shuli He Pingping Li Chunxiao Ma Minglei Ma Yiwen Liu Lu Lv Fan Ping Huabing Zhang Wei Li Qi Sun Lingling Xu Yuxiu Li |
| author_facet | Jie Yu Haibin Liu Shuli He Pingping Li Chunxiao Ma Minglei Ma Yiwen Liu Lu Lv Fan Ping Huabing Zhang Wei Li Qi Sun Lingling Xu Yuxiu Li |
| author_sort | Jie Yu |
| collection | DOAJ |
| description | Objectives. In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs. The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). However, few epidemiological studies have evaluated the effects of magnesium on LTL in the clinical setting. Participants. This cross-sectional analysis included 467 participants (34.8% men). Measurements. Serum blood lipid profile, HbA1c, oxidative stress, and proinflammatory mediator levels were measured. Detailed dietary data were obtained using a 24 h food recall. LTL was assessed using a real-time PCR assay. Regression models and simple regulatory models were used for data analysis. Results. There was an inverse relationship between dietary magnesium and LTL (P<0.001), with a between-extreme-quarter difference of -0.55. Conversely, there was a positive relationship between dietary magnesium and serum tumor necrosis factor (TNF) α, with an interquarter difference of 3.79 pmol/mL (P for trend=0.006). Multivariate regression analysis revealed that the odds ratios (ORs) for shorter LTL and higher serum TNFα increased with magnesium intake, and the ORs of the differences between extreme quartiles were 2.60 (95% confidence interval (CI): 1.31–5.36; P=0.003) and 1.98 (95% CI: 1.09–3.59; P=0.008). There was a direct negative effect of dietary magnesium intake on LTL (B=−0.002; P=0.001), which appeared to be indirectly influenced by TNFα (-0.002 to -0.0005). Conclusions. Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNFα. |
| format | Article |
| id | doaj-art-11898c82451243a4b717cf5fb6b68b9b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-11898c82451243a4b717cf5fb6b68b9b2025-02-03T06:05:18ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/76104367610436Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor αJie Yu0Haibin Liu1Shuli He2Pingping Li3Chunxiao Ma4Minglei Ma5Yiwen Liu6Lu Lv7Fan Ping8Huabing Zhang9Wei Li10Qi Sun11Lingling Xu12Yuxiu Li13Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Basic Physiology, The Health School Affiliated to Capital Medical University, ChinaDepartment of Nutrition, Peking Union Medical College Hospital, Beijing 100730, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing 100050, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing 100730, ChinaObjectives. In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs. The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). However, few epidemiological studies have evaluated the effects of magnesium on LTL in the clinical setting. Participants. This cross-sectional analysis included 467 participants (34.8% men). Measurements. Serum blood lipid profile, HbA1c, oxidative stress, and proinflammatory mediator levels were measured. Detailed dietary data were obtained using a 24 h food recall. LTL was assessed using a real-time PCR assay. Regression models and simple regulatory models were used for data analysis. Results. There was an inverse relationship between dietary magnesium and LTL (P<0.001), with a between-extreme-quarter difference of -0.55. Conversely, there was a positive relationship between dietary magnesium and serum tumor necrosis factor (TNF) α, with an interquarter difference of 3.79 pmol/mL (P for trend=0.006). Multivariate regression analysis revealed that the odds ratios (ORs) for shorter LTL and higher serum TNFα increased with magnesium intake, and the ORs of the differences between extreme quartiles were 2.60 (95% confidence interval (CI): 1.31–5.36; P=0.003) and 1.98 (95% CI: 1.09–3.59; P=0.008). There was a direct negative effect of dietary magnesium intake on LTL (B=−0.002; P=0.001), which appeared to be indirectly influenced by TNFα (-0.002 to -0.0005). Conclusions. Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNFα.http://dx.doi.org/10.1155/2020/7610436 |
| spellingShingle | Jie Yu Haibin Liu Shuli He Pingping Li Chunxiao Ma Minglei Ma Yiwen Liu Lu Lv Fan Ping Huabing Zhang Wei Li Qi Sun Lingling Xu Yuxiu Li Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α Mediators of Inflammation |
| title | Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α |
| title_full | Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α |
| title_fullStr | Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α |
| title_full_unstemmed | Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α |
| title_short | Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α |
| title_sort | dietary magnesium intake and leukocyte telomere attrition in adults the regulatory role of serum tumor necrosis factor α |
| url | http://dx.doi.org/10.1155/2020/7610436 |
| work_keys_str_mv | AT jieyu dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT haibinliu dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT shulihe dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT pingpingli dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT chunxiaoma dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT mingleima dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT yiwenliu dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT lulv dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT fanping dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT huabingzhang dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT weili dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT qisun dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT linglingxu dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora AT yuxiuli dietarymagnesiumintakeandleukocytetelomereattritioninadultstheregulatoryroleofserumtumornecrosisfactora |