Targeted delivery of liposomal senolytics to alleviate cellular senescence-induced bone loss

Targeted delivery of liposomal senolytics to alleviate cellular senescence-induced bone loss

The senescence of bone marrow-derived mesenchymal stem cells is involved in osteoporosis. The combination of dasatinib and quercetin has been explored to alleviate bone loss by efficiently reducing senescent cell populations. However, senolytic therapy by dasatinib and quercetin requires a precise r...

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Main Authors: Rong Li, Yaohua Wei, Changhao Xiong, Jingwei Wang, Yixuan Lin, Ronghui Deng, Hao Qin, Yang Chen, Nan Li, Guyu Zheng, Yuanyuan Lv, Jian Shi, Tingting Yu, Yiye Li, Jing Wang, Ruifang Zhao, Changsheng Liu, Guangjun Nie
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2025-07-01
Series:Fundamental Research
Subjects:
Bone targeting
Cellular senescence
Dasatinib
Quercetin
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667325824005314
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http://www.sciencedirect.com/science/article/pii/S2667325824005314

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