Total neoadjuvant therapy integrating long-course radiotherapy with trifluridine/tipiracil for locally advanced rectal cancer: a single-arm, multicenter phase 2 trialResearch in context

Total neoadjuvant therapy integrating long-course radiotherapy with trifluridine/tipiracil for locally advanced rectal cancer: a single-arm, multicenter phase 2 trialResearch in context

Summary: Background: Total neoadjuvant therapy (TNT) is recommended for locally advanced rectal cancer (LARC) with high-risk factors. The objective of this multi-center phase 2 study is to evaluate the impact of a newly designed TNT consist of TAS-102 concurrent with long-course radiotherapy follow...

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Main Authors: Xue Dou, Lina Zhao, Zhenyu Ma, Lichun Wei, Xin Jiang, Yi Ding, Shichang Sun, Yanlai Sun, Minghuan Li, Rui Feng, Kunli Zhu, Fang Shi, Kai Liu, Minghao Li, Yongsheng Gao, Peng Su, Shanshan Li, Jinming Yu, Jinbo Yue
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EClinicalMedicine
Subjects:
Locally advanced rectal cancer
Total neoadjuvant therapy
Long-course radiotherapy
Trifluridine/tipiracil
Pathological complete response
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025002445
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