Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway

Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway

IntroductionAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline; recent studies suggest that neuronal ferroptosis plays a key role in its pathogenesis. Danggui Shaoyao San (DSS), a traditional Chinese medicine formula, has shown demonstrated neuroprotective ef...

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Main Authors: Kai Gong, Shuang Zhou, Li Xiao, Mengzhen Xu, Yuhe Zhou, Kaihui Lu, Xin Yu, Jiang Zhu, Chuanguo Liu, Qingjun Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
neuron ferroptosis
AMPK/Sp1/ACSL4 pathway
Danggui Shaoyao San
lipid metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1588375/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1588375/full

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