Control of motor coordination by transient receptor potential melastatin 8 through γ-aminobutyric acidergic circuit modulation in the male mouse cerebellum

Control of motor coordination by transient receptor potential melastatin 8 through γ-aminobutyric acidergic circuit modulation in the male mouse cerebellum

Abstract Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel that is activated by mild cooling and chemical agents. Although TRPM8 is widely expressed in the peripheral and central nervous systems, its cerebellar distribution and functional significance remain unexplo...

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Main Authors: Mayuka Koyama, Koki Harada, Naoko Takizawa, Shinji Kobuchi, Miwa Kambara, Hikaru Tanaka, Riona Araki, Yuri Yamada, Yukako Ito, Kazuyuki Takata, Shinichi Kato, Kenjiro Matsumoto
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Cerebellum
Transient receptor potential melastatin 8
Interneuron
GABA
Motor coordination
Rotarod test
Online Access:https://doi.org/10.1038/s41598-025-98837-9
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https://doi.org/10.1038/s41598-025-98837-9

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