Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe

Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe

Introduction: The farnesoid X receptor (FXR) is a crucial regulator in the intestine, maintaining bile acid homeostasis. Inhibiting intestinal FXR shows promise in managing inflammatory bowel and liver diseases by reducing bile acid accumulation. Additionally, changes in FXR expression could serve a...

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Bibliographic Details
Main Authors: Dou Niu, Xiaolei Wu, Yuxin Zhang, Xueliang Wang, Daniel Shiu-Hin Chan, Shaozhen Jing, Chun-Yuen Wong, Wanhe Wang, Chung-Hang Leung
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Advanced Research
Subjects:
Iridium complex
FXR
Nuclear receptor
Tailoring activity
Imaging probe
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224004831
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