Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo.

Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo.

Rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) poses enormous challenge in the development of broad-spectrum antivirals that are effective against the existing and emerging viral strains. Virus entry through endocytosis represents an attra...

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Main Authors: Nirmal Kumar, Irshad Maajid Taily, Charandeep Singh, Sahil Kumar, Raju S Rajmani, Debajyoti Chakraborty, Anshul Sharma, Priyanka Singh, Krishan Gopal Thakur, Raghavan Varadarajan, Rajesh P Ringe, Prabal Banerjee, Indranil Banerjee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011358
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https://doi.org/10.1371/journal.ppat.1011358

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