Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular CarcinomaSummary

Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular CarcinomaSummary

Background & Aims: Hepatocellular carcinoma (HCC) is a rapidly growing malignancy with high mortality. Recently, metabolic dysfunction-associated steatohepatitis (MASH) has emerged as a major HCC catalyst; however, signals driving transition of MASH to HCC remain elusive and treatment option...

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Main Authors: Ying Xia, Mara Caputo, Emma Andersson, Bernice Asiedu, Jingjing Zhang, Wei Hou, Manoj Amrutkar, Emmelie Cansby, Nadia Gul, Anne Gemmink, Caitlyn Myers, Mariam Aghajan, Sheri Booten, Andrew J. Hoy, Anetta Härtlova, Per Lindahl, Anders Ståhlberg, Gert Schaart, Matthijs K.C. Hesselink, Andreas Peter, Sue Murray, Margit Mahlapuu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Antisense Oligonucleotide Therapy
Hepatocellular Carcinoma
Metabolic Dysfunction-associated Steatohepatitis
STK25
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25000268
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