Spontaneous and perturbation-based EEG cortical excitability markers are associated with plasma p-tau181 concentration in healthy middle-aged adults

Spontaneous and perturbation-based EEG cortical excitability markers are associated with plasma p-tau181 concentration in healthy middle-aged adults

In early-stage Alzheimer's disease (AD) amyloid-β (Aβ) deposition can induce neuronal hyperactivity, thereby potentially triggering activity-dependent neuronal secretion of phosphorylated tau (p-tau), ensuing tau aggregation and spread. Therefore, cortical excitability is a candidate biomarker...

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Main Authors: Ruben Perellón-Alfonso, Kilian Abellaneda-Pérez, Indre Pileckyte, María Cabello-Toscano, Lídia Mulet-Pons, Lídia Vaqué-Alcázar, Gabriele Cattaneo, María Redondo-Camós, Goretti España-Irla, Selma Delgado-Gallen, Javier Solana Sánchez, Henrik Zetterberg, Jose M. Tormos, Nicolai Franzmeier, Alvaro Pascual-Leone, David Bartrés-Faz
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Alzheimer's disease
Tau
EEG
Transcranial magnetic stimulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024171496
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