A specific role for endothelial EPLIN-isoform-regulated actin dynamics in neutrophil transmigration

A specific role for endothelial EPLIN-isoform-regulated actin dynamics in neutrophil transmigration

Abstract Proinflammatory cytokines such as TNF-α or IL-1β activate the endothelium promoting leukocyte transendothelial migration (TEM) via expression of cell adhesion molecules (CAM) and cause actin remodelling. However, the function of endothelial actin remodelling in TEM remains elusive, despite...

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Main Authors: Mohammed Aldirawi, Parisa Ghanbari, Magdalena Mietkowska, Sigrid März, Maria Odenthal-Schnittler, Jonas Franz, Julian Wegner, Silke Currie, Jan Philip Kipcke, Muna Taha, Marcus Giglmaier, Anja Blanque, Hermann Schillers, Erez Raz, Dietmar Vestweber, Klemens Rottner, Hans Schnittler
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Transendothelial migration
Cell junction dynamics
Arp2/3 complex
Lamellipodia
Stress fibres
VL
Online Access:https://doi.org/10.1038/s41598-025-98192-9
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https://doi.org/10.1038/s41598-025-98192-9

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