Mechanistic Insights into the Mechanism of Allosteric Inhibition of Ubiquitin-Specific Protease 7 (USP7)

Mechanistic Insights into the Mechanism of Allosteric Inhibition of Ubiquitin-Specific Protease 7 (USP7)

Ubiquitin-specific protease 7 (USP7), a deubiquitinase enzyme responsible for removing ubiquitin (Ub) from target proteins, plays a crucial role in oncogenic pathways and has been implicated in various human diseases. X-ray crystallography has revealed distinct conformations of USP7, including apo (...

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Bibliographic Details
Main Authors: Xuebin Wang, Ning Liu, Nuan Li, Shaoyong Lu, Zongtao Chai
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
molecular dynamics simulations
conformational dynamics
allosteric inhibition
protein–protein interactions
allosteric communication
Online Access:https://www.mdpi.com/2218-273X/15/6/749
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