Inhibition of breast cancer resistance protein by flavonols: in vitro, in vivo, and in silico implications of the interactions

Inhibition of breast cancer resistance protein by flavonols: in vitro, in vivo, and in silico implications of the interactions

Abstract Breast cancer resistance protein (BCRP), a member of the ATP-binding cassette transporter family, plays a key role in the efflux of various drugs and is linked to multidrug resistance in cancer therapy. Flavonoids, particularly those with a flavonol backbone, have shown promise as inhibitor...

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Bibliographic Details
Main Authors: Kyeong-Ryoon Lee, Min-Ji Kang, Min Ju Kim, Yiseul Im, Hyeon-Cheol Jeong, Yoon-Jee Chae
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Breast cancer resistance protein
Flavonols
Drug interactions
Drug resistance
SN-38
Online Access:https://doi.org/10.1038/s41598-025-13908-1
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https://doi.org/10.1038/s41598-025-13908-1

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