Modular Calcium‐Responsive and CD9‐Targeted Phospholipase System Enhancing Endosomal Escape for DNA Delivery

Modular Calcium‐Responsive and CD9‐Targeted Phospholipase System Enhancing Endosomal Escape for DNA Delivery

Abstract Gene delivery systems must overcome multiple barriers, with endosomal escape representing a prominent obstacle. We have previously shown that a bacterial phospholipase C (PLC) enabled endosomal escape of a non‐viral protein‐based DNA delivery system termed TFAMoplex. Building upon this, thi...

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Bibliographic Details
Main Authors: Alexander Klipp, Christina Greitens, David Scherer, Alexander Elsener, Jean‐Christophe Leroux, Michael Burger
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
calcium‐responsive system
CD9 targeting
DNA delivery
endosomal escape
phospholipase C
Online Access:https://doi.org/10.1002/advs.202410815
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https://doi.org/10.1002/advs.202410815

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